Led by captain and number eight Sergio Parisse, the Azzurri will be keen to avoid another Wooden Spoon as they begin their 2019 campaign.
Parisse starts in the middle of a strong back-row, alongside Abraham Steyn and Sebastian Negri, with David Sisi and Dean Budd the locks.
Up front, the experienced Leonardo Ghiraldini starts in the hooker jersey and will pack down with props Andrea Lovotti and Simone Ferrari.
O’Shea names Tito Tebaldi and Tommaso Allan as his half-backs while there’s a Six Nations return for Michele Campagnaro on the wing. He’s joined by Angelo Esposito and Jayden Hayward in the back three. Tommaso Castello and Luca Morisi complete the side in the centres.
Italy: 15 Jayden Hayward, 14 Angelo Esposito, 13 Luca Morisi, 12 Tommaso Castello, 11 Michele Campagnaro, 10 Tommaso Allan, 9 Tito Tebaldi, 8 Sergio Parisse (c), 7 Abraham Steyn, 6 Sebastian Negri, 5 Dean Budd, 4 David Sisi, 3 Simone Ferrari, 2 Leonardo Ghiraldini, 1 Andrea Lovotti
Replacements: 16 Luca Bigi, 17 Cherif Traore’ 18 Tiziano Pasquali, 19 Federico Ruzza, 20 Jimmy Tuivaiti, 21 Guglielmo Palazzani, 22 Ian McKinley, 23 Edoardo Padovani